Health What is ALCL?

26 November 2019

Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) is a cancer of the immune system. In most cases, BIA-ALCL is found in the scar tissue and fluid near the implant. An individual’s risk of developing BIA-ALCL is considered to be low. In most patients, it is treated successfully with surgery to remove the implant and surrounding scar tissue. The main symptoms of BIA-ALCL are persistent swelling, presence of a mass or pain in the area of the breast implant.

Diagnostic guidelines

If you experience any of these symptoms or other changes, the American health agency (FDA) recommends that you notify your healthcare provider for further evaluation. 1 Evaluation for BIA-ALCL typically involves a physical exam, imaging, and/or assessment of the fluid or tissue around the breast implant.

Sebbin at the forefront of the investigations

Certain types of textures were recently banned by a couple of countries because they would represent a higher risk for developing BIA-ALCL, without the exact origin of the pathology being known. As soon as the first warning was issued by the FDA in 2016 on a possible association between some breast implant surfaces and the onset of BIA-ALCL, Groupe SEBBIN decided to launch in collaboration with two cutting-edge laboratories a PhD thesis on the biocompatibility of textures, which is now completed. The results of this thesis, like the establishment of a biologically-relevant classification of textures 2, were published in several scientific and medical journals.

  1. https://www.fda.gov/medical-devices/breast-implants/questions-and-answers-about-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl[]
  2. “Surface texturation of breast implant impacts extracellular matrix and inflammatory gene expression in asymptomatic capsule. Plastic and reconstructive surgery”, Brigaud I, Garabedian C, Bricout N, Pieuchot L, Ponche A, Deltombe R, et al. Dec 23, 2019.[]

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